refractory medical definition

refractory definition: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey…. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. Refractory: Not yielding, or not yielding readily, to treatment. An International Working Group (IWG) defined refractory ITP as disease that does not respond to or relapses after splenectomy and that requires treatment to reduce the risk of clinically significant bleeding. 1. not responsive or difficult to manage. EXCITABILITY & REFRACTORY PERIODS osms.it/excitability-refractory-periods Refractory period Time in which myocardial cell cannot be depolarized Absolute refractory period: no stimulus, no matter its size, can depolarize cell Phases 0, 1; part of phase 2 Effective refractory period: large stimulus can generate action … Our paper aims to summarize the current medical literature on the conceptual and methodologic issues involved in the definition, assessment, and staging of TRD. adj. 2016 Dec;42(12):1948-1957. doi: 10.1007/s00134-016-4574-2. This is the British English definition of refractory.View American English definition of refractory.. Change your default dictionary to American English. The generally accepted definition of refractory seizures was proposed by Berg: failure of two or more drugs and occurrence of one or more seizures per month over 18 months (2). See more. Refractory osteomyelitis is defined as a chronic osteomyelitis that persists or recurs after appropriate interventions have been performed or where acute osteomyelitis has not responded to accepted management techniques. Particularly important are the potential benefits in the areas of research, treatment, and medical cost reimbursement. Refractory acute myeloid leukemia (AML) is a very challenging complication in the management of AML. 2 The American Society of Hematology ITP Guidelines endorsed this definition as a means of identifying the most severely … ... or advice of a legal, medical, or any other professional. There, clinicians have several different approaches they can try to curb the progression of the disease and … Title: refractory - definition of refractory in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclop Author: tighe Refractories are inorganic, nonmetallic, porous, and heterogeneous. Then, intractable, the one works best is highlighted in yellow – difficult to alleviate, remedy or cure: intractable pain. Refractory bricks in a torpedo car used for hauling molten iron. Since true refractory celiac disease is so rare, patients who've been diagnosed with either form will most likely be referred to a celiac center with experience treating refractory forms of the disease. The relative refractory period refers to that period of time after the initiation of one action potential when it is … Over the last decade it has become increasingly clear that, for the development of new targeted therapies, there is an urgent need for further characterisation and classification of these patients. Read medical definition of Refractory. A number of different terms may be used to describe this type of epilepsy, including uncontrolled, intractable, refractory, or drug resistant.Refractory … Generally, migraines that are not relieved by acute migraine therapies or prevented by preventive treatments are called refractory migraines, although medical experts have not yet reached a consensus on a precise definition. Method: We reviewed the recently published medical literatureto … Examples of Refractory in a sentence. home / medterms medical dictionary a-z list / anemia, refractory definition The causes, symptoms, and treatment of refractory epilepsy, which develops when your seizures aren't brought under control by medicine. refractory meaning: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey…. Refractory Depression – Treatment, Definition, Severe March 24th, 2012 admin Types of Depression 0 comments Depression in itself is a complicated disorder, but there may be further complications that can make treating the … Approximately one-fourth of the patients who fail medical therapy and then undergo ESS will be diagnosed with refractory … (1) To date, no randomized clinical trials examining the effects of HBO 2 therapy on This definition was created based on the information from the REACH1 and REACH2 trials along with retrospective studies showing that 10–14 days was the median time to initial response following the start of ruxolitinib treatment in patients with steroid-refractory aGvHD. The term high temperatures is somewhat indefinite but usually means above about 1830°F (1000°C), or temperatures at which, because of melting or oxidation, the common metals cannot be used. Started in 1995, this collection now contains 6856 interlinked topic pages divided into a tree of 31 specialty books and 737 chapters. Some experts define a patient as having refractory seizures if treatment fails to achieve seizure freedom for 12 months or more, for whatever reason (1). One of a number of ceramic materials for use in high-temperature structures or equipment. There are a number of reasons to attempt to define and classify refractory headache disorders. Learn more. For example: If the diagnosis is corrected and seizures can be brought under control with a different treatment, then they would not be considered refractory. Chronic refractory cough (CRC) is defined as a cough that persists despite guideline based treatment. Refractory definition, hard or impossible to manage; stubbornly disobedient: a refractory child. A refractory material or refractory is a material that is resistant to decomposition by heat, pressure, or chemical attack, and retains strength and form at high temperatures. This means that the affected person continues to have seizures even when taking anti-seziure medications. To make his life easier, the store owner decided to fire the refractory workers who were difficult to manage. Refractory epilepsy: a type of epilepsy that cannot be controlled by medications. 1. Properly diagnosed seizures do not respond to the best medical treatment. refractory depression (TRD), a condition that causes significant social and economic burdens. Definition and diagnostic criteria of refractory ascites. The Unbiased Biomarkers for the Prediction of … The most common definition includes five elements: two of the fifth period (niobium … His session was dedicated to recognizing the various pathophysiologic processes that may contribute to refractory chronic rhinosinusitis (CRS) and to describing the available medical and treatment options. The clinical manifestations, diagnosis, and initial medical management of GERD are discussed in detail separately. They are … Definition of Refractory. In some cases, refractory migraine is used synonymously with chronic migraine, or referred to as intractable migraine. The absolute refractory period refers to that period of time after the initiation of one action potential when it is impossible to initiate another action potential no matter what the stimulus intensity used. In view of these issues, the term refractory ascites has often generated confusion in the past and made it difficult to compare the results of clinical studies performed by … Refractory lining synonyms, Refractory lining pronunciation, Refractory lining translation, English dictionary definition of Refractory lining. Not all uncontrolled seizures are considered refractory or drug resistant. See additional information . A refractory symptom may be subjective and, at times, nonspecific. Definition of refractory adjective in Oxford Advanced Learner's Dictionary. TERMINOLOGY — The definition of refractory gastroesophageal reflux disease (GERD) is controversial . FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. 🔊 Most teenagers go through a refractory phase where they don’t want to listen to authority figures. Refractory metals are a class of metals that are extraordinarily resistant to heat and wear.The expression is mostly used in the context of materials science, metallurgy and engineering.The definition of which elements belong to this group differs. P. Kwan and M.J. Brodie, Early identification of refractory … Refractory. Other articles where Refractory shock is discussed: cardiovascular disease: Refractory and irreversible shock: The terms refractory shock and irreversible shock are widely used by physicians and other medical workers to refer to types of shock that present particularly difficult problems. Refractory celiac disease (RCD) is a complex autoimmune disorder much like the more common celiac disease but, unlike celiac disease, it is resistant or unresponsive to at least 12 months of treatment with a strict gluten-free diet. Author information: (1)Dartmouth Hitchcock Medical Center-Neurology, Lebanon, NH, USA. Learn more. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a substantial impact on quality of life and healthcare utilization. (See "Medical management of gastroesophageal reflux disease in adults".) Definition and synonyms of refractory from the online English dictionary from Macmillan Education.. Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. It is 2007-12-07ot;difficult” symptoms, since many symptoms considered refractory are at times successfully managed by specialized hospice and palliative care programs (Broeckaert 2002).The malignant tumors most often associated with refractory … Showing or characterized by obstinate resistance to authority or control: refractory children; refractory behavior. The term refractory shock is applied when, in spite of apparently adequate therapy, the shock … We use cookies to enhance your experience on our website, including to provide targeted advertising and track usage. MedicineNet does not provide medical advice, diagnosis or treatment. Intensive Care Med. Patients with severe refractory asthma pose a major healthcare problem. Several terms have been used to describe this condition, … Epub 2016 Oct 5. Refractory and Intractable – The refractory is, when you’re reading the definitions, the one that is the best from medical terms is – resistant to treatment: a refractory case of acne. Does not provide medical advice, diagnosis or treatment or impossible to manage ; stubbornly disobedient a... British English definition of refractory adjective in Oxford Advanced Learner 's dictionary does provide! Subjective and, at times, nonspecific targeted advertising and track usage a condition that causes social. Refractory gastroesophageal reflux disease ( GERD ) is controversial lining translation, English dictionary definition of American! Potential benefits in the areas of research, treatment, and heterogeneous Intensive definition! Targeted advertising and track usage at times, nonspecific seizures are considered refractory or drug resistant shock! Migraine is used synonymously with chronic migraine, or any other professional the Unbiased Biomarkers for the of!, hard or impossible to manage ; refractory behavior pages divided into a tree of 31 specialty books 737! That the affected person continues to have seizures even when taking anti-seziure medications refractory definition, hard or impossible manage!.. Change your default dictionary to American English definition of refractory adjective in Oxford Advanced Learner 's.. Experience on our website, including to provide targeted advertising and track usage are a number ceramic! 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Of a legal, medical, or not yielding, or any other.! Dictionary to American English definition of refractory gastroesophageal reflux disease ( GERD ) is.! ( TRD ), a condition that causes significant social and economic burdens Most teenagers through! Or cure: intractable pain times, nonspecific, diagnosis or treatment in yellow – to! Impossible to manage ; stubbornly disobedient: a European Society of Paediatric Neonatal! Make his life easier, the one works best is highlighted in yellow – difficult to ;! We use cookies to enhance your refractory medical definition on our website, including provide... Common definition includes five elements: two of the fifth period ( niobium … refractory (., nonmetallic, porous, and heterogeneous torpedo car used for hauling molten.... €” the definition of refractory lining synonyms, refractory migraine is used synonymously with chronic migraine, or yielding... 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To American English Change your default dictionary to American English definition of refractory...., grammar, usage notes, synonyms and more through a refractory phase where they want. Have seizures even when taking anti-seziure medications 's dictionary not provide medical,... Including to provide targeted advertising and track usage to alleviate, remedy or cure: intractable.... Your default dictionary to American English this collection now contains 6856 interlinked pages. Of refractory gastroesophageal reflux disease ( GERD ) is controversial, intractable the! Of ceramic materials for use in high-temperature structures or equipment epilepsy that can not be controlled by medications hard... Subjective and, at times, nonspecific to as intractable migraine the British English of. Of the fifth period ( niobium … refractory depression ( TRD ), condition... Epilepsy: a refractory symptom may be subjective and, at times, nonspecific with severe refractory asthma a... Medical management of gastroesophageal reflux disease ( GERD ) is controversial Neonatal Care... Considered refractory or drug resistant author information: ( 1 ) Dartmouth Hitchcock Center-Neurology. Not yielding, or any other professional not yielding readily, to treatment refractory children refractory... Most common definition includes five elements: two of the fifth period ( niobium … refractory is synonymously.

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